sunitinib induced immune thrombocytopenia

نویسندگان

ramin shekarriz md, board certified hematologist-oncologist, assistant professor, department of hematology-oncology, cancer research center, imam khomeini hospital, mazandaran university of medical sciences, sari, iran

neda koulaeinejad pharmd, resident of clinical pharmacy, faculty of pharmacy, mazandaran university of medical sciences, sari, iran

anahita nosrati md, board certified pathologist, assistant professor, department of pathology, imam khomeini hospital, mazandaran university of medical sciences, sari, iran

ebrahim salehifar pharmd, board certified clinical pharmacist, associated professor, department of clinical pharmacy, pharmaceutical research center, mazandaran university of medical sciences, sari, iran

چکیده

sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. it was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. it has several adverse reactions on multi organ systems including hematologic system. although the neutropenia and thrombocytopenia commonly happens as grade 3 or 4 abnormalities following bone marrow suppression, in the rare cases, the immune mediated abnormality may drive the sunitinib-induced hematologic disorder. in this report, we present a case of immune-mediated thrombocytopenia induced by sunitinib. one month after first treatment cycle with sunitinib, leucopenia and thrombocytopenia were occurred. the patient had a normal bone marrow aspiration and biopsy, the thrombocytopenia was resistant to platelet transfusion which successfully was treated with prednisolone.

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Sunitinib Induced Immune Thrombocytopenia

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عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۴، شماره ۴، صفحات ۱۲۹۵-۱۲۹۷

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